Development and Application of a Validated Liquid Chromatography-Mass Spectrometry Method for the Determination of Dexchlorpheniramine Maleate in Human Plasma
نویسندگان
چکیده مقاله:
A convenient liquid chromatographic-single Quadrupole mass spectrometric (LC-MS) method was developed and validated for dexchlorpheniramine maleate (INN name: chlorphenamine) determination in human plasma. The need for just a single liquid-liquid extraction with ethyl acetate and being highly sensitive were the advantages of this method. The linearity was also excellent over the range of 1 to 150 ng.ml-1 of dexchlorpheniramine maleate concentration. The method was statistically validated for its selectivity, linearity, precision and robustness. This method was successfully applied to the analysis of chlorpheniramine maleate in clinical studies.
منابع مشابه
development and application of a validated liquid chromatography-mass spectrometry method for the determination of dexchlorpheniramine maleate in human plasma
a convenient liquid chromatographic-single quadrupole mass spectrometric (lc-ms) method was developed and validated for dexchlorpheniramine maleate (inn name: chlorphenamine) determination in human plasma. the need for just a single liquid-liquid extraction with ethyl acetate and being highly sensitive were the advantages of this method. the linearity was also excellent over the range of 1 to 1...
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عنوان ژورنال
دوره 3 شماره 3
صفحات 161- 170
تاریخ انتشار 2007-07-01
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